TLK1 rabbit pAb
Produktgrößen
50UL
£ POA
ES8116-50UL
100UL
£ POA
ES8116-100UL
Über dieses Produkt
- SKU:
- ES8116
- Zusätzliche Namen:
- TLK1; KIAA0137; Serine/threonine-protein kinase tousled-like 1; PKU-beta; Tousled-like kinase 1
- Anwendung:
- Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.;cofactor:Magnesium.;enzyme regulation:Cell-cycle regulated; maximal activity in S-phase. Inactivated by phosphorylation at Ser-743; potentially by CHK1.;function:Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23; augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro; phosphorylates histone H3 at 'Ser-10'.;similarity:Belongs to the protein kinase superfamily.;similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.;similarity:Contains 1 protein kinase domain.;subunit:Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.;tissue specificity:Widely expressed. Present in fetal placenta; liver; kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human TLK1. AA range:730-779
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
