Tensin3 rabbit pAb
Produktgrößen
50UL
£ POA
ES7196-50UL
100UL
£ POA
ES7196-100UL
Über dieses Produkt
- SKU:
- ES7196
- Zusätzliche Namen:
- TNS3; TEM6; TENS1; TPP; Tensin-3; Tensin-like SH2 domain-containing protein 1; Tumor endothelial marker 6
- Anwendung:
- Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development.;induction:EGF induces down-regulation.;PTM:Epidermal growth factor(EGF) induces tyrosine phosphorylation in a time- and dose-dependent manner.;similarity:Contains 1 C2 tensin-type domain.;similarity:Contains 1 phosphatase tensin-type domain.;similarity:Contains 1 SH2 domain.;subunit:EGF promotes the interaction with EGFR. Interacts with PTK2 and BCAR1. Tyrosine phosphorylation is critical for these interactions.;tissue specificity:Expressed in umbilical vein endothelial cells; epithelial cells; and fibroblasts cells (at protein level). Highly expressed in thyroid; kidney and placenta. Low expression in heart; skeletal muscle; spleen; liver; and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human TENS3. AA range:541-590
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
