Raf-1 (phospho Ser621) rabbit pAb
Produktgrößen
50UL
£ POA
ES6982-50UL
100UL
£ POA
ES6982-100UL
Über dieses Produkt
- SKU:
- ES6982
- Zusätzliche Namen:
- RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K); which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated; the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2; which in turn phosphorylate to activate the serine/threonine specific protein kinases; ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle; apoptosis; cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq; Jul 2008];
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human C-RAF around the phosphorylation site of Ser621. AA range:591-640
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat, Non-human Primate
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
