AR (phospho Ser213) rabbit pAb
Produktgrößen
50UL
£ POA
ES5934-50UL
100UL
£ POA
ES5934-100UL
Über dieses Produkt
- SKU:
- ES5934
- Zusätzliche Namen:
- AR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
- Anwendung:
- Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain; DNA-binding domain; and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand; the receptor dissociates from accessory proteins; translocates into the nucleus; dimerizes; and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Androgen Receptor around the phosphorylation site of Ser213. AA range:186-235
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
