IgG1 rabbit pAb
Produktgrößen
50UL
£ POA
ES5860-50UL
100UL
£ POA
ES5860-100UL
Über dieses Produkt
- SKU:
- ES5860
- Zusätzliche Namen:
- IGHG1; Ig gamma-1 chain C region
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- disease:Chromosomal aberrations involving IGHG1 may be a cause of multiple myeloma [MIM:254500]. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.;miscellaneous:Disease protein OMM may represent an allelic form or another gamma chain subclass.;miscellaneous:Disease protein WIS is lacking most of the V region and all of the CH1 region.;miscellaneous:Disease protein ZUC lack most of the V region; all of the CH1 region; and part of the hinge compared with normal gamma-3 heavy chains.;miscellaneous:EU also differs in the amidation states of residues 155; 166; 177; 195; 198; 269; and 272 and in the order of residues 268-272.;miscellaneous:KOL also differs in the amidation states of residues 198; 267 and 272.;miscellaneous:Nie also differs in the amidation states of 35; 116; 198; 269 and 272.;miscellaneous:Nie has the G1M(17) allotypic marker; 97-K; and the G1M(1) markers; 239-D and 241-L. KOL and EU sequences have the G1M(3) marker and the G1M (non-1) markers.;miscellaneous:The hinge region in gamma-3 chains is about four times as long as in other gamma chains and contains three identical 15-residue segments preceded by a similar 17-residue segment (12-28).;online information:IGHM mutation db;polymorphism:All 4 combinations of the S/G and V/G polymorphisms at positions 191 and 216 have been observed in human mu chains.;subcellular location:During differentiation; B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.;subunit:Dimer linked by 12 disulfide bonds; it has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human IgG1. AA range:196-245
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
