VN2R1P rabbit pAb
Produktgrößen
50UL
£ POA
ES5835-50UL
100UL
£ POA
ES5835-100UL
Über dieses Produkt
- SKU:
- ES5835
- Anwendung:
- Western Blot, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The CARL-1 monoclonal antibody reacts with human TWEAK; a type II transmembrane TNF superfamily member with high identity to TNF in its extracellular portion. TWEAK transcript is expressed broadly in many adult and fetal tissues; however; the staining of human peripheral blood mononuclear cells with monoclonal antibodies shows a more restricted pattern. While freshly isolated PBMCs do not express detectable levels of TWEAK on their surface; IFN-gamma-stimulated blood monocytes rapidly upregulate TWEAK surface expression. TWEAK is expressed as membrane bound and secreted forms. Interaction of TWEAK with its counter-receptor promotes secretion of IL-8; activation of NF-kappaB; proliferation of endothelial cells; and apoptosis in a number of human cell lines. Initially; DR3 was thought to be a receptor for TWEAK; but further studies have shown that TWEAK could induce apoptosis via receptors distinct from DR3. While TWEAK exhibits overlapping signaling functions to TNF; it is generally less effective in inducing apoptosis; giving rise to its name; TNF-like weak inducer of apoptosis. For detection of human TWEAK by sandwich ELISA; a combination of purified CARL-2 for capture and biotinylated CARL-1 for detection is recommended.
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CASRL1. AA range:400-449
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
