UBN-1 rabbit pAb
Produktgrößen
50UL
£ POA
ES5694-50UL
100UL
£ POA
ES5694-100UL
Über dieses Produkt
- SKU:
- ES5694
- Zusätzliche Namen:
- UBN1; Ubinuclein-1; HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF); which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.;similarity:Belongs to the ubinuclein family.;subcellular location:Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA; PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed; accumulates in the nucleus in cells showing defective cytokinesis.;subunit:Component of a complex that includes at least ASF1A; CABIN1; HIRA; histone H3.3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain); the interaction is direct. Interacts with ASF1A; CEBPA; TJP1; TJP2 and TJP3.;tissue specificity:Ubiquitous. Also expressed in numerous tumors and cancer cell lines.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Ubinuclein. AA range:161-210
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
