ERK 8 (phospho Thr175/Y177) rabbit pAb
Produktgrößen
50UL
£ POA
ES5241-50UL
100UL
£ POA
ES5241-100UL
Über dieses Produkt
- SKU:
- ES5241
- Zusätzliche Namen:
- MAPK15; ERK7; ERK8; Mitogen-activated protein kinase 15; MAP kinase 15; MAPK 15; Extracellular signal-regulated kinase 7; ERK-7; Extracellular signal-regulated kinase 8; ERK-8
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.;domain:The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteosomal degradation.;domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.;enzyme regulation:Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases; such as DUSP1.;function:In vitro; phosphorylates MBP.;PTM:Dually phosphorylated on Thr-175 and Tyr-177; which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro.;PTM:Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase.;similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.;similarity:Contains 1 protein kinase domain.;subunit:Interacts with CSK/c-Src; ABL1; RET and TGFB1I1.;tissue specificity:Widely expressed with a maximal expression in lung and kidney.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human ERK8 around the phosphorylation site of Thr175 and Tyr177. AA range:141-190
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
