DNA pol ι rabbit pAb
Produktgrößen
50UL
£ POA
ES4614-50UL
100UL
£ POA
ES4614-100UL
Über dieses Produkt
- SKU:
- ES4614
- Zusätzliche Namen:
- POLI; RAD30B; DNA polymerase iota; Eta2; RAD30 homolog B
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).;cofactor:Magnesium.;domain:The catalytic core consists of fingers; palm and thumb subdomains; but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints; with consequently higher rates of misincorporation and low processivity.;function:Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis; where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template; where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites; but may not have lyase activity.;similarity:Belongs to the DNA polymerase type-Y family.;similarity:Contains 1 umuC domain.;subcellular location:Accumulates at replication forks after DNA damage.;subunit:Binds REV1L (By similarity). Binds POLH.;tissue specificity:Ubiquitous. Highly expressed in testis.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human POLI. AA range:641-690
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
