DNA pol θ rabbit pAb
Produktgrößen
50UL
£ POA
ES4538-50UL
100UL
£ POA
ES4538-100UL
Über dieses Produkt
- SKU:
- ES4538
- Zusätzliche Namen:
- POLQ; POLH; DNA polymerase theta; DNA polymerase eta
- Anwendung:
- Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- POLQ (Polymerase (DNA) Theta) is a Protein Coding gene. Among its related pathways are Platinum Pathway; Pharmacokinetics/Pharmacodynamics and DNA Double-Strand Break Repair. GO annotations related to this gene include nucleic acid binding and damaged DNA binding. An important paralog of this gene is SNRNP200. NA polymerase that promotes microhomology-mediated end-joining (MMEJ); an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA (PubMed: 25642963; PubMed: 25643323). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements; such as telomere fusions; some of them leading to cellular transformation (PubMed: 25642963; PubMed: 25643323). POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed: 25642963). POLQ-mediated MMEJ may be required to promote the survival of cells with a compromised HR repair pathway; thereby preventing genomic havoc by resolving unrepaired lesions (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks; allowing microhomologous sequences in the overhangs to form base pairs. It then extends each strand from the base-paired region using the opposing overhang as a template. Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed: 25643323). The polymerase activity is highly promiscuous: unlike most polymerases; promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed: 18503084; PubMed: 21050863; PubMed: 22135286). Also exhibits low-fidelity DNA synthesis; translesion synthesis and lyase activity; and it is implicated in interstrand-cross-link repair; base excision repair and DNA end-joining (PubMed: 14576298; PubMed: 18503084; PubMed: 19188258; PubMed: 24648516). Involved in somatic hypermutation of immunoglobulin genes; a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity).
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human POLQ. AA range:181-230
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
