SLAM rabbit pAb
Produktgrößen
50UL
£ POA
ES4009-50UL
100UL
£ POA
ES4009-100UL
Über dieses Produkt
- SKU:
- ES4009
- Zusätzliche Namen:
- SLAMF1; SLAM; Signaling lymphocytic activation molecule; CDw150; IPO-3; CD150
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- domain:The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues.;function:High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.;PTM:Phosphorylated by FYN.;similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.;similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.;subcellular location:Present on the surface of B-cells and T-cells.;subunit:Its cytoplasmic domain interacts with SH2 domain protein 1A (SH2D1A); and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus HN protein and acts as a receptor for this virus.;tissue specificity:Constitutively expressed on peripheral blood memory T-cells; T-cell clones; immature thymocytes; and a proportion of B-cells; and is rapidely induced on naive T-cells after activation.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from the Internal region of human SLAMF1. AA range:81-130
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
