TCF-1 rabbit pAb
Produktgrößen
50UL
£ POA
ES3572-50UL
100UL
£ POA
ES3572-100UL
Über dieses Produkt
- SKU:
- ES3572
- Zusätzliche Namen:
- TCF7; TCF1; Transcription factor 7; TCF-7; T-cell-specific transcription factor 1; T-cell factor 1; TCF-1
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- alternative products:2 series of isoforms; L and S; are produced by use of alternative promoter usage. Additional isoforms seem to exist;function:Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1; TLE2; TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.;induction:By TCF7L2 and CTNNB1.;sequence caution:Wrong choice of frame.;similarity:Belongs to the TCF/LEF family.;similarity:Contains 1 HMG box DNA-binding domain.;subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES; TLE1; TLE2; TLE3 and TLE4.;tissue specificity:Predominantly in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human TCF7. AA range:10-59
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
