Pinin rabbit pAb
Produktgrößen
50UL
£ POA
ES3210-50UL
100UL
£ POA
ES3210-100UL
Über dieses Produkt
- SKU:
- ES3210
- Zusätzliche Namen:
- PNN; DRS; MEMA; Pinin; 140 kDa nuclear and cell adhesion-related phosphoprotein; Desmosome-associated protein; Domain-rich serine protein; DRS protein; DRSP; Melanoma metastasis clone A protein; Nuclear protein SDK3; SR-like protein
- Anwendung:
- Western Blot, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Also participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.;PTM:Phosphorylated upon DNA damage; probably by ATM or ATR.;similarity:Belongs to the pinin family.;subcellular location:Cell-cell contact area; predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.;subunit:Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Interacts with C6orf111/SRRP130; CTBP1; CTBP2; KRT8; KRT18; KRT19; PS1D/PNO40; PPIG; RNPS1; SFRS4 and SRRM2. Identified in the spliceosome C complex; at least composed of AQR; ASCC3L1; C19orf29; CDC40; CDC5L; CRNKL1; DDX23; DDX41; DDX48; DDX5; DGCR14; DHX35; DHX38; DHX8; EFTUD2; FRG1; GPATC1; HNRPA1; HNRPA2B1; HNRPA3; HNRPC; HNRPF; HNRPH1; HNRPK; HNRPM; HNRPR; HNRPU; KIAA1160; KIAA1604; LSM2; LSM3; MAGOH; MORG1; PABPC1; PLRG1; PNN; PPIE; PPIL1; PPIL3; PPWD1; PRPF19; PRPF4B; PRPF6; PRPF8; RALY; RBM22; RBM8A; RBMX; SART1; SF3A1; SF3A2; SF3A3; SF3B1; SF3B2; SF3B3; SFRS1; SKIV2L2; SNRPA1; SNRPB; SNRPB2; SNRPD1; SNRPD2; SNRPD3; SNRPE; SNRPF; SNRPG; SNW1; SRRM1; SRRM2; SYF2; SYNCRIP; TFIP11; THOC4; U2AF1; WDR57; XAB2 and ZCCHC8.;tissue specificity:Expressed in placenta; lung; liver; kidney; pancreas; spleen; thymus; prostate; testis; ovary; small intestine; colon; heart; epidermis; esophagus; brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primary tumors.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human PNN. AA range:211-260
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
