p53RFP rabbit pAb
Produktgrößen
50UL
£ POA
ES3129-50UL
100UL
£ POA
ES3129-100UL
Über dieses Produkt
- SKU:
- ES3129
- Zusätzliche Namen:
- RNF144B; IBRDC2; P53RFP; E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- caution:Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.;domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.;function:E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2; thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism.;pathway:Protein modification; protein ubiquitination.;PTM:Auto-ubiquitinated.;similarity:Belongs to the RBR family. RNF144 subfamily.;similarity:Contains 1 IBR-type zinc finger.;similarity:Contains 2 RING-type zinc fingers.;subunit:Interacts with UBE2L3; UBE2L6 and LCMT2.;tissue specificity:Broadly expressed; with lowest levels in brain; spleen and thymus.;
- Immunogen:
- Synthesized peptide derived from the Internal region of human p53RFP.
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
