Neddylin rabbit pAb
Produktgrößen
50UL
£ POA
ES2913-50UL
100UL
£ POA
ES2913-100UL
Über dieses Produkt
- SKU:
- ES2913
- Zusätzliche Namen:
- NEDD8; NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity; and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.;PTM:Cleavage of precursor form by UCHL3 or SENP8 is necessary for function.;similarity:Belongs to the ubiquitin family.;subcellular location:Mainly nuclear.;subunit:Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53.;tissue specificity:Highly expressed in heart; skeletal muscle; spleen; thymus; prostate; testis; ovary; colon and leukocytes.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human NEDD8. AA range:10-59
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat, Non-human Primate
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
