MYSM1 rabbit pAb
Produktgrößen
50UL
£ POA
ES2883-50UL
100UL
£ POA
ES2883-100UL
Über dieses Produkt
- SKU:
- ES2883
- Zusätzliche Namen:
- MYSM1; KIAA1915; Histone H2A deubiquitinase MYSM1; 2A-DUB; Myb-like; SWIRM and MPN domain-containing protein 1
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.;domain:Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA.;function:Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A; a specific tag for epigenetic transcriptional repression; thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.;PTM:Phosphorylated upon DNA damage; probably by ATM or ATR.;similarity:Belongs to the peptidase M67A family. MYSM1 subfamily.;similarity:Contains 1 MPN (JAB/Mov34) domain.;similarity:Contains 1 SANT domain.;similarity:Contains 1 SWIRM domain.;subunit:Component of a large chromatin remodeling complex; at least composed of MYSM1; PCAF; RBM10 and KIF11/TRIP5. Binds histones.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MYSM1. AA range:520-569
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
