MSK1 rabbit pAb
Produktgrößen
50UL
£ POA
ES2860-50UL
100UL
£ POA
ES2860-100UL
Über dieses Produkt
- SKU:
- ES2860
- Zusätzliche Namen:
- RPS6KA5; MSK1; Ribosomal protein S6 kinase alpha-5; S6K-alpha-5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.;cofactor:Magnesium.;enzyme regulation:Appears to be activated by multiple phosphorylations on threonine and serine residues. ERK1/2 and MAPK14/p38-alpha may play a role in this process.;function:Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics; stress stimuli and epidemal growth-factor (EGF); which results in the transcriptional activation of several immediate early genes; including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).;miscellaneous:Enzyme activity requires the presence of both kinase domains.;PTM:Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain; and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain.;similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.;similarity:Contains 1 AGC-kinase C-terminal domain.;similarity:Contains 2 protein kinase domains.;subcellular location:Predominantly nuclear. Partially cytoplasmic.;subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.;tissue specificity:Widely expressed with high levels in heart; brain and placenta. Less abundant in lung; kidney and liver.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MSK1. AA range:551-600
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
