Phospho PKC θ (Y90) rabbit pAb
Produktgrößen
50UL
£ POA
ES20173-50UL
100UL
£ POA
ES20173-100UL
Über dieses Produkt
- SKU:
- ES20173
- Zusätzliche Namen:
- Protein kinase C theta type (EC 2.7.11.13;nPKC-theta)
- Anwendung:
- Western Blot, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:ATP + a protein = ADP + a phosphoprotein.;cofactor:Magnesium.;domain:The C1 domain; containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B); is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.;enzyme regulation:Three specific sites; Thr-538 (activation loop of the kinase domain); Ser-676 (turn motif) and Ser-695 (hydrophobic region); need to be phosphorylated for its full activation.;function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters; a class of tumor promoters.;function:This is a calcium-independent; phospholipid-dependent; serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation; but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.;PTM:Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.;similarity:Belongs to the protein kinase superfamily.;similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.;similarity:Contains 1 AGC-kinase C-terminal domain.;similarity:Contains 1 C2 domain.;similarity:Contains 1 protein kinase domain.;similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.;subunit:Interacts with TXNL2/PICOT.;tissue specificity:Skeletal muscle; megakaryoblastic cells and platelets.;
- Immunogen:
- Synthesized peptide derived from human Phospho PKC θ (Y90)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
