JAK3 (Phospho Tyr981) rabbit pAb
Produktgrößen
50UL
£ POA
ES20172-50UL
100UL
£ POA
ES20172-100UL
Über dieses Produkt
- SKU:
- ES20172
- Zusätzliche Namen:
- Tyrosine-protein kinase JAK3 (EC 2.7.10.2;Janus kinase 3;JAK-3;Leukocyte janus kinase;L-JAK)
- Anwendung:
- Western Blot, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.;disease:Defects in JAK3 are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-negative (T(-)B(+)NK(-)SCID) [MIM:600802]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity; leukopenia; and low or absent antibody levels. Patients with SCID present in infancy with recurrent; persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.;domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity); while the presence of slight differences suggest a different role for domain 1.;function:Tyrosine kinase of the non-receptor type; involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6; IRS1; IRS2 and PI3K.;online information:JAK3 mutation db;PTM:Tyrosine phosphorylated in response to IL-2 and IL-4.;similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.;similarity:Contains 1 FERM domain.;similarity:Contains 1 protein kinase domain.;similarity:Contains 1 SH2 domain.;subcellular location:Wholly intracellular; possibly membrane associated.;subunit:Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.;tissue specificity:In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines; whereas the B- and M-forms are detected in cells both of hematopoietic and epithelial origins.;
- Immunogen:
- Synthesized peptide derived from human JAK3 (Phospho Tyr981)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
