Met (Phospho Tyr1235) rabbit pAb
Produktgrößen
50UL
£ POA
ES20169-50UL
100UL
£ POA
ES20169-100UL
Über dieses Produkt
- SKU:
- ES20169
- Zusätzliche Namen:
- Hepatocyte growth factor receptor (HGF receptor;EC 2.7.10.1;HGF/SF receptor;Proto-oncogene c-Met;Scatter factor receptor;SF receptor;Tyrosine-protein kinase Met)
- Anwendung:
- Western Blot, ELISA, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.;disease:Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.;disease:Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550].;disease:Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple; bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.;disease:Defects in MET may be associated with gastric cancer.;disease:Genetic variations in MET may be associated with susceptibility to autism type 9 (AUTS9) [MIM:611015]. Autism is a neurodevelopmental disorder characterized by disturbance in language; perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication; a lack of reciprocal social interaction or responsiveness; and restricted; stereotypical; and ritualized patterns of interests and behavior.;domain:The kinase domain is involved in SPSB1 binding.;function:Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation; scattering; morphogenesis and survival.;online information:C-MET entry;similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.;similarity:Contains 1 protein kinase domain.;similarity:Contains 1 Sema domain.;similarity:Contains 3 IPT/TIG domains.;subunit:Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1; SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356; interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10; as well as SPSB1; SPSB2; SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF; however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation.;
- Immunogen:
- Synthesized peptide derived from human Met (Phospho Tyr1235)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
