Smad1 (Phospho Ser214) rabbit pAb
Produktgrößen
50UL
£ POA
ES20159-50UL
100UL
£ POA
ES20159-100UL
Über dieses Produkt
- SKU:
- ES20159
- Zusätzliche Namen:
- Mothers against decapentaplegic homolog 1 (MAD homolog 1;Mothers against DPP homolog 1;JV4-1;Mad-related protein 1;SMAD family member 1;SMAD 1;Smad1;hSMAD1;Transforming growth factor-beta-signaling protein 1;BSP-1)
- Anwendung:
- Western Blot, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).;PTM:Phosphorylated on serine by BMP type 1 receptor kinase.;PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.;similarity:Belongs to the dwarfin/SMAD family.;similarity:Contains 1 MH1 (MAD homology 1) domain.;similarity:Contains 1 MH2 (MAD homology 2) domain.;subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.;subunit:Interacts with HGS; NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit; CREB-binding protein (CBP); p300; SMURF1; SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.;tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.;
- Immunogen:
- Synthesized peptide derived from human Smad1 (Phospho Ser214)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
