Stat2 (Acetyl Lys384) rabbit pAb
Produktgrößen
50UL
£ POA
ES20131-50UL
100UL
£ POA
ES20131-100UL
Über dieses Produkt
- SKU:
- ES20131
- Zusätzliche Namen:
- Signal transducer and activator of transcription 2 (p113)
- Anwendung:
- Western Blot, ELISA, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors; Jak kinases (TYK2 and JAK1) are activated; leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize; associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor; that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes; which drive the cell in an antiviral state.;PTM:Tyrosine phosphorylated in response to IFN-alpha.;similarity:Belongs to the transcription factor STAT family.;similarity:Contains 1 SH2 domain.;subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta.;subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.;
- Immunogen:
- Synthesized peptide derived from human Stat2 (Acetyl Lys384)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
