Stat1 (Acetyl Lys410/K413) rabbit pAb
Produktgrößen
50UL
£ POA
ES20130-50UL
100UL
£ POA
ES20130-100UL
Über dieses Produkt
- SKU:
- ES20130
- Zusätzliche Namen:
- Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
- Anwendung:
- Western Blot, ELISA, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- disease:Defects in STAT1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species; such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria; and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections; with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood; whereas others develop; later in life; disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive; autosomal dominant or X-linked inheritance.;disease:Defects in STAT1 are the cause of STAT1 deficiency [MIM:600555]. Patients generally suffer from mycobacterial or viral diseases. In the case of complete deficiency; patients can die of viral disease.;function:Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors; Jak kinases (TYK2 and JAK1) are activated; leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize; associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor; that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes; which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma); STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF); migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes; inducing a cellular antiviral state.;online information:STAT1 entry;online information:STAT1 mutation db;PTM:Phosphorylated on tyrosine and serine residues in response to IFN-alpha; IFN-gamma; PDGF and EGF. Phosphorylation on Tyr-701 (lacking in beta form) by JAK promotes dimerization and subsequent translocation to the nucleus. Phosphorylation on Ser-727 by several kinases including MAPK14; ERK1/2 and CAMKII on IFN-gamma stimulation; regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PKCdelta induces apoptosis in response to DNA-damaging agents.;PTM:Sumoylated by SUMO1; SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727; and by interaction with PIAS proteins. Enhances the transactivation activity.;similarity:Belongs to the transcription factor STAT family.;similarity:Contains 1 SH2 domain.;subcellular location:Translocated into the nucleus in response to IFN-gamma-induced tyrosine phosphorylation and dimerization.;subunit:Isoform alpha homodimerizes upon IFN-gamma induced phosphorylation. Heterodimer with STAT2 upon IFN-alpha/beta induced phosphorylation. Interacts with NMI. Interacts with Sendai virus C'; C; Y1 and Y2 proteins; Nipah virus P; V and W proteins; and rabies virus phosphoprotein preventing activation of ISRE and GAS promoter (By similarity). Interacts with HCV core protein; the interaction results in STAT1 degradation. Interacts with PIAS1; the interaction requires phosphorylation on Ser-727 and inhibits STAT1 activation.;
- Immunogen:
- Synthesized peptide derived from human Stat1 (Acetyl Lys410/K413)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
