HDAC1 (Acetyl Lys432) rabbit pAb
Produktgrößen
50UL
£ POA
ES20096-50UL
100UL
£ POA
ES20096-100UL
Über dieses Produkt
- SKU:
- ES20096
- Zusätzliche Namen:
- Histone deacetylase 1 (HD1;EC 3.5.1.98)
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.;function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A; H2B; H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation; cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.;PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.;PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.;similarity:Belongs to the histone deacetylase family. Type 1 subfamily.;subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1; HDAC2; RBBP4 and RBBP7. The core complex associates with MTA2; MBD2; MBD3; MTA1L1; CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex; or with SIN3; SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1; HDAC2; HMG20B/BRAF35; AOF2/LSD1; RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2; ZNF217; ZMYM3; GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BCOR; BRMS1L; DAXX; DNMT1; EP300; HCFC1; NFE4; PCAF; PHB2; MIER1; KDM4A; MINT; NRIP1; PRDM6; RERE; SETDB1; SUV39H1; TGIF; TGIF2; UHRF1; UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Interacts with HDAC9. Component of a mSin3A corepressor complex that contains SIN3A; SAP130; SUDS3/SAP45; ARID4B/SAP180; HDAC1 and HDAC2. Interacts with BANP; CBFA2T3 and KDM5B. Interacts with SAP30L. Interacts with E4F1. Interacts with KFL1 (By similarity). Interacts with SV40 large T antigen.;tissue specificity:Ubiquitous; with higher levels in heart; pancreas and testis; and lower levels in kidney and brain.;
- Immunogen:
- Synthesized peptide derived from human HDAC1 (Acetyl Lys432)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody