FoxO4 (Acetyl Lys407) rabbit pAb
Produktgrößen
50UL
£ POA
ES20069-50UL
100UL
£ POA
ES20069-100UL
Über dieses Produkt
- SKU:
- ES20069
- Zusätzliche Namen:
- Forkhead box protein O4 (Fork head domain transcription factor AFX1)
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein.;function:Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.;pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32; Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival; transformation and tumorigenicity.;PTM:Acetylation by CBP; which is induced by peroxidase stress; inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.;PTM:Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization.;similarity:Contains 1 fork-head DNA-binding domain.;subcellular location:When phosphorylated; translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.;subunit:Interacts with CBP; MYOCD; SIRT1; SRF and YWHAZ. Acetylated by CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding.;tissue specificity:Heart; brain; placenta; lung; liver; skeletal muscle; kidney and pancreas. Isoform zeta is most abundant in the liver; kidney; and pancreas.;
- Immunogen:
- Synthesized peptide derived from human FoxO4 (Acetyl Lys407)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody