ERα (Acetyl Lys303) rabbit pAb
Produktgrößen
50UL
£ POA
ES20065-50UL
100UL
£ POA
ES20065-100UL
Über dieses Produkt
- SKU:
- ES20065
- Zusätzliche Namen:
- Estrogen receptor (ER;ER-alpha;Estradiol receptor;Nuclear receptor subfamily 3 group A member 1)
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- domain:Composed of three domains: a modulating N-terminal domain; a DNA-binding domain and a C-terminal steroid-binding domain.;function:Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.;online information:Estrogen receptor entry;polymorphism:Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density; disrutption of bone microarchitecture; and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.;PTM:Glycosylated; contains N-acetylglucosamine; probably O-linked.;PTM:Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.;similarity:Belongs to the nuclear hormone receptor family.;similarity:Belongs to the nuclear hormone receptor family. NR3 subfamily.;similarity:Contains 1 nuclear receptor DNA-binding domain.;subunit:Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3; NCOA5 and NCOA6 coactivators; leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2; PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2; FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.;
- Immunogen:
- Synthesized peptide derived from human ERα (Acetyl Lys303)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody