E2F-2 (Acetyl Lys122) rabbit pAb
Produktgrößen
50UL
£ POA
ES20062-50UL
100UL
£ POA
ES20062-100UL
Über dieses Produkt
- SKU:
- ES20062
- Zusätzliche Namen:
- Transcription factor E2F2 (E2F-2)
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site; 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to RB1 protein; in a cell-cycle dependent manner.;PTM:Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.;similarity:Belongs to the E2F/DP family.;subunit:Component of the DRTF1/E2F transcription factor complex. Forms heterodimers with DP family members. The E2F-2 complex binds specifically hypophosphorylated retinoblastoma protein RB1. During the cell cycle; RB1 becomes phosphorylated in mid-to-late G1 phase; detaches from the DRTF1/E2F complex; rendering E2F transcriptionally active. Viral oncoproteins; notably E1A; T-antigen and HPV E7; are capable of sequestering RB protein; thus releasing the active complex. Binds EAPP.;tissue specificity:Highest level of expression is found in placenta; low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.;
- Immunogen:
- Synthesized peptide derived from human E2F-2 (Acetyl Lys122)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody