Bcl-6 (Acetyl Lys379) rabbit pAb
Produktgrößen
50UL
£ POA
ES20058-50UL
100UL
£ POA
ES20058-100UL
Über dieses Produkt
- SKU:
- ES20058
- Zusätzliche Namen:
- B-cell lymphoma 6 protein (BCL-6;B-cell lymphoma 5 protein;BCL-5;Protein LAZ-3;Zinc finger and BTB domain-containing protein 27;Zinc finger protein 51)
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.;disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.;disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.;function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.;induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS; CD40L and zymosan.;PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.;similarity:Contains 1 BTB (POZ) domain.;similarity:Contains 6 C2H2-type zinc fingers.;subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.;tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.;
- Immunogen:
- Synthesized peptide derived from human Bcl-6 (Acetyl Lys379)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody