Histone H4 (Tri Methyl Lys21) rabbit pAb
Produktgrößen
50UL
£ POA
ES20050-50UL
100UL
£ POA
ES20050-100UL
Über dieses Produkt
- SKU:
- ES20050
- Zusätzliche Namen:
- Histone H4
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin; limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation; DNA repair; DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones; also called histone code; and nucleosome remodeling.;PTM:Acetylation at Lys-6; Lys-9; Lys-13 and Lys-17 occurs in coding regions of the genome but not in heterochromatin.;PTM:Citrullination at Arg-4 by PADI4 impairs methylation.;PTM:Monomethylated; dimethylated or trimethylated at Lys-21. Monomethylation is performed by SET8. Trimethylation is performed by SUV420H1 and SUV420H2 and induces gene silencing.;PTM:Monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 and Lys-13. Demethylation is performed by JMJD6.;PTM:Sumoylated; which is associated with transcriptional repression.;PTM:Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.;similarity:Belongs to the histone H4 family.;subunit:The nucleosome is a histone octamer containing two molecules each of H2A; H2B; H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.;
- Immunogen:
- Synthesized peptide derived from human Histone H4 (Tri Methyl Lys21)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody