THRB (heavy chain; Cleaved-Ile364) rabbit pAb
Produktgrößen
50UL
£ POA
ES20044-50UL
100UL
£ POA
ES20044-100UL
Über dieses Produkt
- SKU:
- ES20044
- Zusätzliche Namen:
- Prothrombin (EC 3.4.21.5;Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
- Anwendung:
- Western Blot, ELISA, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.;disease:Defects in F2 are the cause of various forms of dysprothrombinemia [MIM:176930].;disease:Genetic variations in F2 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor; sensory and/or cognitive function. Ischemic strokes; resulting from vascular occlusion; is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.;function:Thrombin; which cleaves bonds after Arg and Lys; converts fibrinogen to fibrin and activates factors V; VII; VIII; XIII; and; in complex with thrombomodulin; protein C. Functions in blood homeostasis; inflammation and wound healing.;miscellaneous:It is not known whether 1 or 2 smaller activation peptides; with additional cleavage after Arg-314; are released in natural blood clotting.;miscellaneous:Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial; small amounts of thrombin.;miscellaneous:The cleavage after Arg-198; observed in vitro; does not occur in plasma.;miscellaneous:Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin; prior to its activation by factor Xa.;online information:Thrombin entry;pharmaceutical:The peptide TP508 also known as Chrysalin (Orthologic) could be used to accelerate repair of both soft and hard tissues.;PTM:The gamma-carboxyglutamyl residues; which bind calcium ions; result from the carboxylation of glutamyl residues by a microsomal enzyme; the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface; which is essential for the conversion of prothrombin to thrombin.;similarity:Belongs to the peptidase S1 family.;similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.;similarity:Contains 1 peptidase S1 domain.;similarity:Contains 2 kringle domains.;tissue specificity:Expressed by the liver and secreted in plasma.;
- Immunogen:
- Synthesized peptide derived from human THRB (heavy chain; Cleaved-Ile364)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
