NOTCH1 (Cleaved-Val1711) rabbit pAb
Produktgrößen
50UL
£ POA
ES20038-50UL
100UL
£ POA
ES20038-100UL
Über dieses Produkt
- SKU:
- ES20038
- Zusätzliche Namen:
- Neurogenic locus notch homolog protein 1 (Notch 1;hN1;Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation; Notch 1 intracellular domain (NICD)]
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- disease:Defects in NOTCH1 are a cause of aortic valve disease [MIM:109730]. The disorder consists of an early developmental defect in the aortic valve and a later de-repression of calcium deposition that causes progressive aortic valve disease. Calcification of the aortic valve is the third leading cause of heart disease in adults. The incidence increases with age; and it is often associated with a bicuspid aortic valve present in 1-2% of the population.;disease:NOTCH1 truncation is associated with T-cell acute lymphoblastic leukemia.;function:Functions as a receptor for membrane-bound ligands Jagged1; Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation; proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form; may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development; may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia.;PTM:Phosphorylated.;PTM:Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active; ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding; it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.;similarity:Belongs to the NOTCH family.;similarity:Contains 3 LNR (Lin/Notch) repeats.;similarity:Contains 36 EGF-like domains.;similarity:Contains 5 ANK repeats.;subcellular location:Following proteolytical processing NICD is translocated to the nucleus.;subunit:Heterodimer of a C-terminal fragment N(TM) and an N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER; DTX1; DTX2 and RBPSUH. Also interacts with MAML1; MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1.;tissue specificity:In fetal tissues most abundant in spleen; brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.;
- Immunogen:
- Synthesized peptide derived from human NOTCH1 (Cleaved-Val1711)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody