MMP9 (Cleaved-Met94) rabbit pAb
Produktgrößen
50UL
£ POA
ES20031-50UL
100UL
£ POA
ES20031-100UL
Über dieses Produkt
- SKU:
- ES20031
- Zusätzliche Namen:
- Matrix metalloproteinase-9 (MMP-9;EC 3.4.24.35;92 kDa gelatinase;92 kDa type IV collagenase;Gelatinase B;GELB) [Cleaved into: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9]
- Anwendung:
- Western Blot, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:Cleavage of gelatin types I and V and collagen types IV and V.;cofactor:Binds 2 zinc ions per subunit.;cofactor:Binds 3 calcium ions per subunit.;disease:Defects in MMP9 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain.;domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion; thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.;enzyme regulation:Inhibited by histatin-3 1/24 (histatin-5).;function:May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.;induction:Activated by 4-aminophenylmercuric acetate and phorbol ester.;miscellaneous:In the arthritis patient this enzyme might contribute to the pathogenesis of joint destruction and might constitute a useful marker of disease status.;PTM:N- and O-glycosylated.;PTM:Processing of the precursor yields different active forms of 64; 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.;similarity:Belongs to the peptidase M10A family.;similarity:Contains 3 fibronectin type-II domains.;similarity:Contains 4 hemopexin-like domains.;subunit:Exists as monomer; disulfide-linked homodimer; and as a heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form.;tissue specificity:Produced by normal alveolar macrophages and granulocytes.;
- Immunogen:
- Synthesized peptide derived from human MMP9 (Cleaved-Met94)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
