MMP19 (Cleaved-Tyr98) rabbit pAb
Produktgrößen
50UL
£ POA
ES20024-50UL
100UL
£ POA
ES20024-100UL
Über dieses Produkt
- SKU:
- ES20024
- Zusätzliche Namen:
- Matrix metalloproteinase-19 (MMP-19;EC 3.4.24.-;Matrix metalloproteinase RASI;Matrix metalloproteinase-18;MMP-18)
- Anwendung:
- Western Blot, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- alternative products:Additional isoforms seem to exist;catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site.;cofactor:Binds 1 zinc ion per subunit.;cofactor:Calcium.;disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.;domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion; thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.;enzyme regulation:Strongly inhibited by TIMP-2; TIMP-3 and TIMP-4; while TIMP-1 is less efficient.;function:Endopeptidase that degrades various components of the extracellular matrix; such as aggrecan and cartilage oligomeric matrix protein (comp); during development; haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV; laminin; nidogen; nascin-C isoform; fibronectin; and type I gelatin.;PTM:Activated by autolytic cleavage after Lys-97.;similarity:Belongs to the peptidase M10A family.;similarity:Contains 4 hemopexin-like domains.;tissue specificity:Expressed in mammary gland; placenta; lung; pancreas; ovary; small intestine; spleen; thymus; prostate; testis colon; heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.;
- Immunogen:
- Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
