ITGA6 (heavy chain; Cleaved-Arg938) rabbit pAb
Produktgrößen
50UL
£ POA
ES20007-50UL
100UL
£ POA
ES20007-100UL
Über dieses Produkt
- SKU:
- ES20007
- Zusätzliche Namen:
- Integrin alpha-6 (CD49 antigen-like family member F;VLA-6;CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain]
- Anwendung:
- Western Blot, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- alternative products:Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains; two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A; isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms;disease:Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB-PA) [MIM:226730]; also known as aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive disease characterized by mucocutaneous fragility and gastrointestinal atresia; which most commonly affects the pylorus.;function:Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.;PTM:Isoforms containing segment A; but not segment B; are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.;similarity:Belongs to the integrin alpha chain family.;similarity:Contains 7 FG-GAP repeats.;subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21.;tissue specificity:Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart; kidney; placenta; colon; duodenum; myoblasts and myotubes; and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland); isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others; only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).;
- Immunogen:
- Synthesized peptide derived from human ITGA6 (heavy chain; Cleaved-Arg938)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
