FA7 (light chain; Cleaved-Ala61) rabbit pAb
Produktgrößen
50UL
£ POA
ES19995-50UL
100UL
£ POA
ES19995-100UL
Über dieses Produkt
- SKU:
- ES19995
- Zusätzliche Namen:
- Coagulation factor VII (EC 3.4.21.21;Proconvertin;Serum prothrombin conversion accelerator;SPCA;Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.;disease:Defects in F7 are the cause of factor VII deficiency [MIM:227500]. Factor VII deficiency is a rare hereditary hemorrhagic disease. The clinical picture can be very severe; with the early occurrence of intracerebral hemorrhages or hemarthroses; or; in contrast; moderate with cutaneous-mucosal hemorrhages (epistaxis; menorrhagia) or hemorrhages provoked by a surgical intervention. Numerous subjects are completely asymptomatic despite a very low F7 level.;function:Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa; factor XIIa; factor IXa; or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions; factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.;online information:Factor VII entry;online information:The Singapore human mutation and polymorphism database;pharmaceutical:Available under the names Niastase or Novoseven (Novo Nordisk). Used for the treatment of bleeding episodes in hemophilia A or B patients with antibodies to coagulation factors VIII or IX.;polymorphism:Individuals with the Q allele (Gln-413) seems to have a decreased susceptibility to myocardial infarction.;PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.;PTM:The vitamin K-dependent; enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.;similarity:Belongs to the peptidase S1 family.;similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.;similarity:Contains 1 peptidase S1 domain.;similarity:Contains 2 EGF-like domains.;subunit:Heterodimer of a light chain and a heavy chain linked by a disulfide bond.;tissue specificity:Plasma.;
- Immunogen:
- Synthesized peptide derived from human FA7 (light chain; Cleaved-Ala61)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody