c-Abl (phospho-Tyr412) rabbit pAb
Produktgrößen
50UL
£ POA
ES17896-50UL
100UL
£ POA
ES17896-100UL
Über dieses Produkt
- SKU:
- ES17896
- Zusätzliche Namen:
- Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
- Anwendung:
- Western Blot
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes; including cell division; adhesion; differentiation; and response to stress. The activity of the protein is negatively regulated by its SH3 domain; whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation; suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias; most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants; which contain alternative first exons that are spliced to the remaining common exons. [pr
- Immunogen:
- Synthesized phosho peptide around human c-Abl (Tyr412)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody