LATS1/2 (phospho-Ser909) rabbit pAb
Produktgrößen
50UL
£ POA
ES15191-50UL
100UL
£ POA
ES15191-100UL
Über dieses Produkt
- SKU:
- ES15191
- Zusätzliche Namen:
- Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
- Anwendung:
- Western Blot, ELISA, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner; with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity; indicating a role as a negative regulator of CDC2/cyclin A. In addition; the C-terminal kinase domain binds to its own N-terminal region; suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas; ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen
- Immunogen:
- Synthesized phosho peptide around human LATS1/2 (Ser909)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
