Shc (phospho Tyr349) rabbit pAb
Produktgrößen
50UL
£ POA
ES1453-50UL
100UL
£ POA
ES1453-100UL
Über dieses Produkt
- SKU:
- ES1453
- Zusätzliche Namen:
- SHC1; SHC; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1
- Anwendung:
- Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways; the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms; p52Shc and p46Shc; link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms; p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq; Feb 2011];
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Shc around the phosphorylation site of Tyr349. AA range:315-364
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody