Shb (phospho Tyr246) rabbit pAb
Produktgrößen
50UL
£ POA
ES1402-50UL
100UL
£ POA
ES1402-100UL
Über dieses Produkt
- SKU:
- ES1402
- Zusätzliche Namen:
- SHB; SH2 domain-containing adapter protein B
- Anwendung:
- Western Blot, Immunohistochemistry
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- domain:The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA; PDGFRB; FGRFR1; IL2RB; IL2RG; CD3Z and CRK/CrKII.;function:Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1; VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling; interleukin-2 signaling; apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.;PTM:Phosphorylated upon PDGFRA; PDGFRB; TCR; IL2 receptor; FGRF1 or VEGFR2 activation.;similarity:Contains 1 SH2 domain.;subcellular location:Associates with membrane lipid rafts upon TCR stimulation.;subunit:Interacts with PTPN11 (By similarity). Interacts with phosphorylated 'Tyr-720' of the ligand-activated receptor PDGFRA via its SH2 domain. Interacts with the ligand-activated receptors PDGFRB; FGFR1; KDR/VEGFR2; IL2RB and IL2RG. Interacts with EPS8 and V-SRC. Interacts with GRB2 and GRAP. Interacts with CD3Z. Interacts with tyrosine-phosphorylated LAT upon T-cell antigen receptor activation. Interacts with PLCG1. Interacts with ZAP70; LCP2/SLP-76; VAV1 and GRAP2. Interacts with JAK1 and JAK3. Interacts with PTK2/FAK1. Interacts with CRK/CrKII. Interacts with IRS2.;tissue specificity:Widely expressed.;
- Immunogen:
- Synthesized phospho-peptide around the phosphorylation site of human Shb (phospho Tyr246)
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
