Shh rabbit pAb
Produktgrößen
50UL
£ POA
ES13122-50UL
100UL
£ POA
ES13122-100UL
Über dieses Produkt
- SKU:
- ES13122
- Zusätzliche Namen:
- Sonic hedgehog protein (SHH;HHG-1) [Cleaved into: Sonic hedgehog protein N-product; Sonic hedgehog protein C-product]
- Anwendung:
- Immunohistochemistry, Immunofluorescence, Western Blot
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube; the anterior-posterior limb axis; and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila; this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly; the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product; restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE); a d
- Immunogen:
- Synthesized peptide derived from human Shh
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
