Chk2 (phospho Ser516) rabbit pAb
Produktgrößen
50UL
£ POA
ES1287-50UL
100UL
£ POA
ES1287-100UL
Über dieses Produkt
- SKU:
- ES1287
- Zusätzliche Namen:
- CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- In response to DNA damage and replication blocks; cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated; the encoded protein is known to inhibit CDC25C phosphatase; preventing entry into mitosis; and has been shown to stabilize the tumor suppressor protein p53; leading to cell cycle arrest in G1. In addition; this protein interacts with and phosphorylates BRCA1; allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome; a highly penetrant familial cancer phenotype usually associated with inherited mutati
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Chk2 around the phosphorylation site of Ser516. AA range:486-535
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Non-human Primate
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
