LAT2 rabbit pAb
Produktgrößen
50UL
£ POA
ES11943-50UL
100UL
£ POA
ES11943-100UL
Über dieses Produkt
- SKU:
- ES11943
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.;function:Sodium-independent; high-affinity transport of small and large neutral amino acids such as alanine; serine; threonine; cysteine; phenylalanine; tyrosine; leucine; arginine and tryptophan; when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D;L-homocysteine complexes; and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols; via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.;induction:Activity in polarized intestinal cells is regulated by the association between SLC3A2/4F2 (in the SLC3A2/4F2-LAT2 heterodimer) and ICAM1.;miscellaneous:L-leucine transport activity inhibited by small zwitterionic amino acids (i.e. glycine; alanine; serine; threonine asparginine; glutamine; methionine; leucine; isoleucine; valine; phenylalanine; tyrosine; tryptophan; histidine and cysteine) and by glutamine and asparginine. Methionine uptake was inhibited by the L-system substrates L-leucine; 2-amino-bicyclo-(2;2;1)-heptane-2-carboxylate (BCH); L-cysteine and by the MeHg-L-cysteine complex and structurally related S-ethyl-L-cysteine. MeHg-L-cysteine uptake is inhibited by L-methionine; L-leucine; BCH and S-ethyl-L-cysteine. L-leucine uptake was inhibited by L-CNSO.;similarity:Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.;subcellular location:Localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc; is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi.;subunit:Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.;tissue specificity:Strongest expression is observed in kidney and moderate expression in placenta and brain; followed by liver; prostate; testis; ovary; lymph node; thymus; spleen; skeletal muscle and heart. Also expressed in fetal liver as well as in the retinal pigment epithelial cell line ARPE-19 and the intestinal epithelial cell line Caco-2.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse, Rat
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody