SFPQ rabbit pAb
Produktgrößen
50UL
£ POA
ES11760-50UL
100UL
£ POA
ES11760-100UL
Über dieses Produkt
- SKU:
- ES11760
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- alternative products:Additional isoforms seem to exist;caution:Was originally (PubMed:2480877) thought to be myoblast cell surface antigen 24.1D5 and a possible membrane-bound protein ectokinase.;disease:A chromosomal aberration involving SFPQ may be a cause of papillary renal cell carcinoma (PRCC). Translocation t(X;1)(p11.2;p34) with TFE3.;function:DNA- and RNA binding protein; involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II; probably as an heteromer with NONO. Binds to pre-mRNA in spliceosome C complex; and specifically binds to intronic polypyrimidine tracts. Interacts with U5 snRNA; probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro; promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro; stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro; the complex strongly stimulates DNA end joining; binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Transcriptional repression is probably mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors; like RXRA and probably THRA; and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity.;PTM:Arg-7; Arg-9; Arg-19 and Arg-25 are dimethylated; probably to asymmetric dimethylarginine.;PTM:Phosphorylated on multiple serine and threonine residues during apoptosis. In vitro phosphorylated by PKC. Phosphorylation stimulates binding to DNA and D-loop formation; but inhibits binding to RNA.;PTM:The N-terminus is blocked.;similarity:Contains 2 RRM (RNA recognition motif) domains.;subcellular location:Predominantly in nuclear matrix.;subunit:Interacts with PSPC1 (By similarity). Monomer and component of the SFPQ-NONO complex; which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. SFPQ is a component of spliceosome and U5.4/6 snRNP complexes. Interacts with SNRPA/U1A. Component of a snRNP-free complex with SNRPA/U1A. Part of complex consisting of SFPQ; NONO and MATR3. Interacts with polypyrimidine tract-binding protein 1/PTB. Part of a complex consisting of SFPQ; NONO and NR5A1/SF-1. Interacts with RXRA; probably THRA; and SIN3A. Interacts with TOP1. Part of a complex consisting of SFPQ; NONO and TOP1. Interacts with SNRNP70 in apoptotic cells (By similarity). Interacts with RNF43.;
- Immunogen:
- Synthesized peptide derived from part region of human protein AA range: 572-622
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody