TNKS1 rabbit pAb
Produktgrößen
50UL
£ POA
ES11215-50UL
100UL
£ POA
ES11215-100UL
Über dieses Produkt
- SKU:
- ES11215
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.;function:May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1; and thereby contribute to the regulation of telomere length.;PTM:ADP-ribosylated (-auto).;PTM:Phosphorylated on serine residues by MAPK kinases upon insulin stimulation.;similarity:Contains 1 PARP catalytic domain.;similarity:Contains 1 SAM (sterile alpha motif) domain.;similarity:Contains 15 ANK repeats.;subcellular location:Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase; a small fraction of TNKS is found in the nucleus; associated with TERF1.;subunit:Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2.;tissue specificity:Ubiquitous; highest levels in testis.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody