FOG1 rabbit pAb
Produktgrößen
50UL
£ POA
ES10602-50UL
100UL
£ POA
ES10602-100UL
Über dieses Produkt
- SKU:
- ES10602
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- domain:The CCHC-type zinc fingers 1; 5; 6 and 9 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interaction with GATA-type zinc fingers.;function:Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1; GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity; depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2; ITGA2B; alpha- and beta-globin; while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development; in a non-redundant way with ZFPM2/FOG2.;PTM:Phosphorylated upon DNA damage; probably by ATM or ATR.;similarity:Belongs to the FOG (Friend of GATA) family.;similarity:Contains 4 C2H2-type zinc fingers.;similarity:Contains 5 C2HC-type zinc fingers.;subunit:Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1; GATA2 and probably GATA3.;tissue specificity:Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum; stomach; lymph node; liver and pancreas. Expressed in fetal heart; liver and spleen.;
- Immunogen:
- Synthesized peptide derived from human protein . at AA range: 620-700
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
