SOCS7 rabbit pAb
Produktgrößen
50UL
£ POA
ES10321-50UL
100UL
£ POA
ES10321-100UL
Über dieses Produkt
- SKU:
- ES10321
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- domain:The SOCS box domain mediates the interaction with the Elongin BC complex; an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.;function:Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin; growth hormone and leptin signaling by preventing STAT3 and STAT5 activation; sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.;induction:By IL6; prolactin and growth hormone.;pathway:Protein modification; protein ubiquitination.;sequence caution:Contaminating sequence. The N-terminus may be contaminated with vector sequence.;sequence caution:Translated as stop.;similarity:Contains 1 SH2 domain.;similarity:Contains 1 SOCS box domain.;subunit:Interacts with phosphorylated IRS4 and PIK3R1 (By similarity). Interacts; via the third proline-rich region; with the second SH3 domain of the adapter protein NCK1. Also interacts with GRB2; INSR; IRS1; PLCG1; SORBS3/vinexin; and phosphorylated STAT3 and STAT5.;tissue specificity:Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.;
- Immunogen:
- Synthesized peptide derived from part region of human protein
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody