Cleaved-C1r LC (I464) rabbit pAb
Produktgrößen
50UL
£ POA
ES1013-50UL
100UL
£ POA
ES1013-100UL
Über dieses Produkt
- SKU:
- ES1013
- Zusätzliche Namen:
- C1R; Complement C1r subcomponent; Complement component 1 subcomponent r
- Anwendung:
- Western Blot, ELISA
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- catalytic activity:Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).;function:C1r B chain is a serine protease that combines with C1q and C1s to form C1; the first component of the classical pathway of the complement system.;polymorphism:Complement component C1r deficiency [MIM:216950] leads to the failure of the classical complement system activation pathway (C1 deficiency). Individuals with C1 deficiency are highly susceptible to infections by microorganisms and have greater risk in developing autoimmune diseases such as systemic lupus erythematosus (SLE).;PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.;similarity:Belongs to the peptidase S1 family.;similarity:Contains 1 EGF-like domain.;similarity:Contains 1 peptidase S1 domain.;similarity:Contains 2 CUB domains.;similarity:Contains 2 Sushi (CCP/SCR) domains.;subunit:C1 is a calcium-dependent trimolecular complex of C1q; C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains; each of which is activated by cleavage into two chains; A and B; connected by disulfide bonds.;
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human C1R. AA range:445-494
- Isotyp:
- IgG
- Reaktivitäten:
- Human, Rat, Mouse
- Versandbedingungen:
- Blue Ice
- Quelle:
- Rabbit
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- ELK Biotechnology
- Typ:
- Antibodies: Polyclonal Antibody
