Recombinant Human ALCAM (C-Fc)
Produktgrößen
10ug
£ POA
EPT251-10UG
Über dieses Produkt
- SKU:
- EPT251
- Zusätzliche Namen:
- CD166 antigen; Activated leukocyte cell adhesion molecule; CD166; ALCAM; MEMD
- Weitere Details:
- Activated leukocyte cell adhesion molecule (ALCAM); also named as CD166 and MEMD; is a typeI transmembrane glycoprotein of immunoglobulin superfamily; which mediates homotypic and heterotypic interactions between cells. ALCAM is expressed on thymic epithelium; microvascular endothelium; activated lymphocytes and monocytes; and monocytederived dendritic cells. ALCAM mediates low-affinity adhesion with itself or the cysteine-rich scavenger receptor CD6 to regulate T cell development; immunological synapses(IS); and cell migration through endothelial junctions. ALCAM on thymic epithelia mediates adhesion to CD6 on CD4+CD8+ T cells. Adhesion of ALCAM expressing antigen presenting cells and CD6-expressing T cells stabilizes the early IS; while later it enhances CD3 effects on T cell proliferation; CD25 expression; and Th1 commitment. ALCAM may influence expression or adhesion of the neuronal adhesion molecule NCAML1; both in the developing retina and invasive melanoma.
- Molekulargewicht:
- 82.7 KDa
- Reinheit:
- Greater than 95% as determined by reducing SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Hersteller:
- ELK Biotechnology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.