Recombinant Human Serpin A1 (C-6His)
Produktgrößen
10ug
£ POA
EPT244-10UG
Über dieses Produkt
- SKU:
- EPT244
- Zusätzliche Namen:
- Alpha-1-Antitrypsin; Alpha-1 Protease Inhibitor; Alpha-1-Antiproteinase; Serpin A1; SERPINA1; AAT; PI
- Weitere Details:
- Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation; it is synthesized in hepatocytes; and to a lesser extent; in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase; plasmin; thrombin; trypsin; chymotrypsin; and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency; and consequently lead to several clinical complications such as pulmonary emphysema; juvenile hepatitis; cirrhosis; and hepatocellular carcinoma. For example; the Z variants (Glu342 to Lys) forms intracellular inclusion bodies; is not secreted; and leads to a severe SerpinA1 deficiency. Accordingly; Serpin A1 deficiency in circulation is associated with emphysema or liver disease.
- Molekulargewicht:
- 45.35 KDa
- Reinheit:
- Greater than 95% as determined by reducing SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Hersteller:
- ELK Biotechnology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.