Recombinant Human RSPO1 (C-6His)
Produktgrößen
50ug
£ POA
EPT157-50UG
Über dieses Produkt
- SKU:
- EPT157
- Zusätzliche Namen:
- RSPO1; R-spondin1; RP11-566C13.1; CRISTIN3; FLJ40906; RSPO Rspo1; R-spondin; Rspondin; RP23-325M14.2; Roof plate-specific spondin-1
- Weitere Details:
- RSPO1 is a secreted protein;containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads; regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation; it acts synergistically with WNT4. They help stabilize β catenin; which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/β catenin pathway to oppose male sex development. In critical gonadal stages; between six and nine weeks after fertilization; the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis; which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.
- Molekulargewicht:
- 27.8 KDa
- Reinheit:
- Greater than 95% as determined by reducing SDS-PAGE.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Lyophilized protein should be stored at < -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at < -20[o]C for 3 months.
- Hersteller:
- ELK Biotechnology
- Typ:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Recombinant Proteins
- Endotoxin Level:
- Less than 0.01 EU/µg as determined by LAL test.